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methyl β cyclodextrin complexed cholesterol  (MedChemExpress)


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    MedChemExpress methyl β cyclodextrin complexed cholesterol
    Methyl β Cyclodextrin Complexed Cholesterol, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 166 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/methyl+%CE%B2+cyclodextrin+complexed+cholesterol/Methyl-%CE%B2-cyclodextrin/pmc12863058-186-27-68
    Average 97 stars, based on 166 article reviews
    methyl β cyclodextrin complexed cholesterol - by Bioz Stars, 2026-10
    97/100 stars

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    Staining:

    Article Title: Transcriptomic landscape of transposable elements reveals LTR7 - PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma
    Article Snippet: .. For enhanced lipid depletion, DGAT1 and DGAT2 inhibitors (5 μM each) were added during the final 18 h. To induce cholesterol ester accumulation, cells were loaded with methyl-β-cyclodextrin-complexed cholesterol (20:1 molar ratio) in 5% LPDS for 24 h. Cells were fixed with 4% paraformaldehyde in 250 mM Hepes buffer (pH 7.4) containing 100 μM CaCl 2 and 100 μM MgCl 2 and stained with BODIPY 576/589 (10 μM; MCE, #HY-D1118) and Hoechst 33342 (5 μg/mL; MCE, #HY-15559) for lipid droplet and nuclear visualization. .. Confocal images were acquired using a Zeiss LSM 900 microscope under consistent settings.

    Article Title: Transcriptomic landscape of transposable elements reveals LTR7 - PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma.
    Article Snippet: reveals LTR7-PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma Meilong Shi, Chuanqi Teng, Shan Zhang, Xiaobo He, Lingyun Xu, Fengxian Han, Rongqi Wen, Ganjun Yu, Jingwen Liu, Yang Feng, Yanfeng Wu, Yan Ren, Gang Jin, and Jing Li Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, SecondMilitary Medical University (Naval Medical University), Shanghai 200433, China; Center for Translational Medicine, Second Military Medical University (Naval Medical University), Shanghai 200433, China; National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai 200433, China; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Department of Precision Medicine, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China; Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang, Hangzhou 310022, China; State Key Laboratory for Macromolecule Drugs and Large-scale Manufacturing, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325030, China



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    A truncated and cholesterol- resistant form of SM is present in a variety of cell types. A , the indicated cell lines were treated in the presence or the absence of 1 μM NB-598 for 8 h, and immunoblotting was performed for SM and truncated SM (trunSM; red ). Immunoblots are representative of n ≥ 3 (HEK293T, HeLaT, Huh7, and HepG2) or n = 1 (Be(2)-C) independent experiments. B and C , HEK293T cells were treated with 10 μg/ml cycloheximide in the presence or the absence of ( B ) 1 μM NB-598 or ( C ) 20 μg/ml <t>cholesterol-methyl-β-cyclodextrin</t> complexes (Chol/CD) for the indicated times. Graphs depict densitometric quantification of SM levels ( left ), trunSM levels ( center ), or total SM levels (SM + trunSM; right ) normalized to the 0 h time point, which was set to 1 ( dotted line ). Data presented as mean ± SEM from n ≥ 3 independent experiments (∗ p ≤ 0.05; two-tailed paired t test versus vehicle condition). HEK293T, human embryonic kidney 293T; SM, squalene monooxygenase.
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    A truncated and cholesterol- resistant form of SM is present in a variety of cell types. A , the indicated cell lines were treated in the presence or the absence of 1 μM NB-598 for 8 h, and immunoblotting was performed for SM and truncated SM (trunSM; red ). Immunoblots are representative of n ≥ 3 (HEK293T, HeLaT, Huh7, and HepG2) or n = 1 (Be(2)-C) independent experiments. B and C , HEK293T cells were treated with 10 μg/ml cycloheximide in the presence or the absence of ( B ) 1 μM NB-598 or ( C ) 20 μg/ml <t>cholesterol-methyl-β-cyclodextrin</t> complexes (Chol/CD) for the indicated times. Graphs depict densitometric quantification of SM levels ( left ), trunSM levels ( center ), or total SM levels (SM + trunSM; right ) normalized to the 0 h time point, which was set to 1 ( dotted line ). Data presented as mean ± SEM from n ≥ 3 independent experiments (∗ p ≤ 0.05; two-tailed paired t test versus vehicle condition). HEK293T, human embryonic kidney 293T; SM, squalene monooxygenase.
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    A truncated and cholesterol- resistant form of SM is present in a variety of cell types. A , the indicated cell lines were treated in the presence or the absence of 1 μM NB-598 for 8 h, and immunoblotting was performed for SM and truncated SM (trunSM; red ). Immunoblots are representative of n ≥ 3 (HEK293T, HeLaT, Huh7, and HepG2) or n = 1 (Be(2)-C) independent experiments. B and C , HEK293T cells were treated with 10 μg/ml cycloheximide in the presence or the absence of ( B ) 1 μM NB-598 or ( C ) 20 μg/ml cholesterol-methyl-β-cyclodextrin complexes (Chol/CD) for the indicated times. Graphs depict densitometric quantification of SM levels ( left ), trunSM levels ( center ), or total SM levels (SM + trunSM; right ) normalized to the 0 h time point, which was set to 1 ( dotted line ). Data presented as mean ± SEM from n ≥ 3 independent experiments (∗ p ≤ 0.05; two-tailed paired t test versus vehicle condition). HEK293T, human embryonic kidney 293T; SM, squalene monooxygenase.

    Journal: The Journal of Biological Chemistry

    Article Title: The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form

    doi: 10.1016/j.jbc.2021.100731

    Figure Lengend Snippet: A truncated and cholesterol- resistant form of SM is present in a variety of cell types. A , the indicated cell lines were treated in the presence or the absence of 1 μM NB-598 for 8 h, and immunoblotting was performed for SM and truncated SM (trunSM; red ). Immunoblots are representative of n ≥ 3 (HEK293T, HeLaT, Huh7, and HepG2) or n = 1 (Be(2)-C) independent experiments. B and C , HEK293T cells were treated with 10 μg/ml cycloheximide in the presence or the absence of ( B ) 1 μM NB-598 or ( C ) 20 μg/ml cholesterol-methyl-β-cyclodextrin complexes (Chol/CD) for the indicated times. Graphs depict densitometric quantification of SM levels ( left ), trunSM levels ( center ), or total SM levels (SM + trunSM; right ) normalized to the 0 h time point, which was set to 1 ( dotted line ). Data presented as mean ± SEM from n ≥ 3 independent experiments (∗ p ≤ 0.05; two-tailed paired t test versus vehicle condition). HEK293T, human embryonic kidney 293T; SM, squalene monooxygenase.

    Article Snippet: Chemicals were from the following suppliers: ALLN (A6185; Sigma–Aldrich), ammonium chloride (31; Ajax Finechem), l -azidohomoalanine (1066; Click Chemistry Tools), bafilomycin A1 (B1793; Sigma–Aldrich), β-mercaptoethanol (M3148; Sigma–Aldrich), bromophenol blue (B0126; Sigma–Aldrich), butylated hydroxytoluene (B1378; Sigma–Aldrich), [ 14 C]-acetate sodium salt (PerkinElmer; catalog no. NEC084H001MC), CB-5083 (16276; Cayman Chemical Company), cholesterol complexed with methyl-β-cyclodextrin (Chol/CD; C4951; Sigma–Aldrich), chloroform (102444; Supelco), cycloheximide (C7698; Sigma–Aldrich), l -cysteine (168149; Sigma–Aldrich), diethyl ether (code: EA036; Chem-Supply), dimethyl sulfoxide (DMSO) (2225; Ajax Finechem), ethanol (214; Ajax Finechem), glacial acetic acid (100063; Supelco), GlutaMAX (M4667; Thermo Fisher), glycerol (242; Ajax Finechem), glycine (1083; Ajax Finechem), Hepes (54457; Sigma–Aldrich), heptane (LC1078; RCI LabScan), hexane (104369; Supelco), hydrochloric acid (256; Ajax Finechem), IGEPAL CA-630 (I8896; Sigma–Aldrich), magnesium chloride (296; Ajax Finechem), methanol (318; Ajax Finechem), l -methionine (M9625; Sigma–Aldrich), methotrexate (13960; Cayman Chemical Company), mevalonolactone (mevalonate; M4667; Sigma–Aldrich), mevastatin (compactin; M2537; Sigma–Aldrich), MG132 (C2211; Sigma–Aldrich), NB-598 (CS-1274; Chemscene), PEG4 carboxamide-propargyl biotin (1266; Click Chemistry Tools), polyethyleneimine (03880; Sigma–Aldrich), Ponceau S solution (P7170; Sigma–Aldrich), potassium chloride (383; Ajax Finechem), potassium hydroxide (405; Ajax Finechem), PR-619 (16276; Cayman Chemical Company), Ro 48-8071 (10006415; Cayman Chemical Company), sodium carbonate (463; Ajax Finechem), sodium chloride (465; Ajax Finechem), sodium deoxycholate (D6750; Sigma–Aldrich), SDS (75746; Sigma–Aldrich), sodium EDTA (180; Ajax Finechem), sodium EGTA (E8145; Sigma–Aldrich), sodium hydroxide (482; Ajax FineChem), sodium orthovanadate (S6508; Sigma–Aldrich), sodium pyruvate (11360070; Thermo Fisher), Tris (2311; Ajax Finechem), Tween-20 (P9416; Sigma–Aldrich), and WP1130 (15277; Cayman Chemical Company).

    Techniques: Western Blot, Two Tailed Test